Original Research

 

Epidemiological study of lesions associated with mandibular and maxillary bones diagnosed by a brazilian reference center over 11 years

Estudo epidemiológico das lesões associadas à maxila e mandíbula diagnosticadas em centro de referência brasileiro no período de 11 anos

 

Jener Gonçalves de Farias^a,b, Laís Reis Pereira^a, Sheinaz Farias Hassam^b,*, Tarsila de Carvalho Freitas Ramos^a, Antônio Varela Câncio^a,c, Juliana Andrade Cardoso^b

^a State University of Feira de Santana, Brazil ^b UNIME – College of Agrarian Health Sciences, Lauro de Freitas, Brazil

^c CTBMF Service at Clériston Andrade Hospital – SESAB, Feira de Santana, Brazil

 

^*Correspondence to:

 

http://doi.org/10.24873/j.rpemd.2020.11.719

 

Abstract

Objectives: To determine the prevalence of lesions associated with the maxillary bone biopsied from patients assisted at the Reference Centre for Oral Injuries of the State University of Feira de Santana (CRLB – UEFS) from 2006 to 2017, identifying the three most frequent lesions and their clinical characteristics.

Methods: A descriptive, cross-sectional study was carried out to evaluate all the histopathological reports of the last 11 years that included a histopathological diagnosis of bone lesions of the maxilla preconized by the WHO (2017), as well as data on patients, such as gender, age, histopathological diagnosis, and anatomical location. The collected information was input into tables using Microsoft Office Excel Professional Plus Software (2013).

Results: 65 conclusive reports were found for bone lesions of the maxilla, with a prevalence of 0.03. The mean age was 45.2 years, and the female gender and the posterior region of the mandible were the most affected.

Conclusions: The most frequent lesions were cemento-osseous dysplasia, fibrous dysplasia, and ossifying fibroma.

Keywords: Biopsy,Bone Diseases, Prevalence

 

Resumo

Objetivos: Determinar a prevalência das lesões associadas aos ossos maxilares biopsiadas em pacientes atendidos pelo Centro de Referência de Lesões Bucais (CRLB) da Universidade Estadual de Feira de Santana (UEFS) no período de 2006 a 2017, identificando as três lesões mais frequentes e suas características clínicas.

Métodos: Estudo transversal, descritivo, realizado ao avaliar todos as laudos histopatológicos dos últimos 11 anos, que tiveram como diagnóstico histopatológico alguma das lesões associadas aos ossos maxilares preconizadas pela OMS (2017) e dados sobre os pacientes, como: género, idade, diagnóstico histopatológico e localização anatómica. As informações coletadas foram transpostas para tabelas através do Software Microsoft Office Excel Professional Plus (2013).

Resultados: Foram encontrados 65 laudos conclusivos para lesões associadas aos ossos maxilares, com prevalência de 0,03. Os pacientes tiveram idade média de 45,2 anos, geralmente do género feminino e a região posterior da mandíbula como a mais acometida.

Conclusões: As lesões mais frequentes foram a displasia cemento-óssea, displasia fibrosa e fibroma ossificante.

Palavras-chave: Biópsia,Doenças ósseas,Prevalência

 

Introduction

The intra‑osseous lesions that affect the maxillomandibular complex are mainly categorized into three groups: cysts, tumors, and bone‑related lesions.¹ The latter are a group of lesions that share the same basic evolutionary mechanism and are characterized by the replacement of normal bone with a fibrous connective tissue that will gradually undergo mineralization. Although these lesions’ subtypes sometimes present similar microscopic characteristics, each group’s demographic, clinical, and radiological characteristics are unique.²

The World Health Organization (WHO) published the latest odontogenic and maxillofacial bone tumors classification in 2017. It referred to bone‑related lesions as the group of “bone tumors and related lesions,” which was subdivided into fibro‑and chondro‑osseous lesions, giant cell lesions, and bone cysts.³

The subgroup of fibrous and chondro‑osseous lesions includes ossifying fibroma, fibrous dysplasia, cemento‑osseous dysplasia, familial gigantiform cementoma, and osteochondroma.

These lesions present similar clinical characteristics, such as increased soft tissue volume and altered shape of the affected bones, leading to aesthetic and functional losses, like paresthesia and trismus. However, they can also be completely asymptomatic while being identifiable in radiographic examinations, where their appearance varies according to the stage of development. In the early stages, the lesions are radiolucent and well‑defined, while in advanced stages, they become radiopaque with poorly defined borders. Thus, they can be characterized as radiolucent, mixed, radiopaque, or with a ground‑glass appearance.⁴

The subgroups of giant cell lesions and bone cysts are composed of central giant cell granuloma, peripheral giant cell granuloma, cherubism, aneurysmal bone cyst, and simple bone cyst. Histologically, these subgroups’ lesions may present characteristics in common and sometimes disordered due to the presence of multinucleated giant cells. However, radiographic and clinical examinations are pathognomonic for the differential diagnosis of these lesions.⁵

A clinical‑pathological study on lesions affecting the jaws in the southern Iranian population carried out in 2017 found 1,121 intra‑ osseous lesions in the archive of the Department of Oral Pathology in a period of 22 years, comprising 25% of all cases. The group of lesions associated with the maxilla and mandible bones was the second most frequent (15.9% of all cases), with the highest prevalence for central giant cell granuloma (CGCG).¹

Understanding bone‑related lesions that affect the jaws is fundamental for the dentist, who is responsible for the diagnosis and treatment of such diseases. When faced with the clinical characteristics of an injury and its epidemiological profile, the knowledgeable clinician will be capable of guiding their diagnosis toward the most frequent lesions. Thus, epidemiological data, besides contributing to the histopathological diagnosis, help with the prognosis, the therapeutic planning, and the patient’s follow‑up.

There has been a significant increase in epidemiological studies involving the classification of oral diseases, including demographic data. However, most of the studies available focus only on some groups of orofacial lesions, such as oral cancer and potentially malignant lesions, culminating in a lack of studies on intra‑osseous lesions, particularly bone‑relatedlesions.⁶

Unquestionably, epidemiological studies have significant relevance in understanding better the lesions that may occur in the stomatognathic system and the profile of the affected population. Therefore, this article intended to contribute to the literature on bone‑related lesions that may affect the jaws.

The current work aimed to identify the bone‑related lesions of the jaws biopsied in patients treated by the Reference Center for Oral Injuries of the State University of Feira de Santana (CRLB – UEFS) from 2006 to 2017, recognizing the three most frequent injuries and their clinical characteristics.

Material and methods

This cross‑sectional descriptive study used secondary data from the histopathological reports of patients living in Feira de Santana and proximities who sought assistance at the CRLB – UEFS spontaneously, from 2006 to 2017. The data was collected from conclusive histopathological reports of oral bone‑related lesions diagnosed by the CRLB – UEFS pathology laboratory between 2006 and 2017.

The CRLB – UEFS runs as a walk‑in clinic, receiving patients from Feira de Santana and all regional cities of the state of Bahia. All conclusive histopathological reports of any injury associated with the maxilla and the mandible recommended by the WHO (2017), from the 11‑year period, were included in the study. The exclusion criteria were descriptive histopathological reports with the same registry number (in cases where incisional biopsy of an extensive lesion was followed by total surgical removal of that lesion, the second report was considered) and with missing information on the variables studied. Of the 2051 reports, including only 290 with a conclusive diagnosis, 65 were selected as fitting the criteria. All 65 conclusive histopathological reports of lesions associated with the jaws were evaluated, and the following data were extracted: histopathological diagnosis, patient’s gender and age, and anatomical location. The lesions had been diagnosed based on clinical and radiographic examination, as well as incisional biopsies of extensive lesions and excisional biopsies of smaller lesions, with the corresponding histopathological reports.

In surgical removal cases where a subsequent new histopathological report was performed with new analysis, the report’s numbering was maintained to avoid duplication.

Data were recorded in a specialized spreadsheet organized in columns. Only one examiner collected and recorded all data, after previous training and calibration by an experienced stomatologist based on reports analysis.

The variables considered in the study were the patients’ gender (female or male) and age, the lesion’s anatomical location (anterior mandible, posterior mandible, anterior maxilla, and posterior maxilla), and the histopathological diagnosis itself. Despite their relevance, variables like profession, smoking, and drinking were not considered due to not having been filled out on the report.

The data obtained were analyzed descriptively using Microsoft Office Excel Professional Plus Software, 2013. Frequency tables were used for qualitative variables, with their respective percentages. Regarding quantitative variables, the mean was adopted as a descriptive measure. The crude measure of association between the variables age (age group), gender, and anatomical location (maxilla versus mandible and anterior versus posterior) was tested by bivariate analysis using the chi‑square, Cochran’s, and Mantel‑ Haenszel tests. The sample had to be dichotomized into two groups: bone‑related lesions and non‑bone‑related lesions (all intra‑osseous lesions – cysts, tumors, and periapical lesions).

Results

All 2,051 histopathological reports of oral lesions diagnosed by the pathology laboratory of the CRLB – UEFS between 2006 and 2017 were evaluated. Only 290 files had a conclusive histopathological diagnosis for some type of intra‑osseous lesion. Of these, 65 were conclusive for bone‑related lesions of the jaws, representing 3.17% of the total lesions, with a ratio of 1:31.

These lesions occurred more frequently in female patients (81.54%) and affected mostly the posterior region of the mandible (53.85%) (Figure 1). The patients’ ages ranged from 10 to 77 years, with a mean age of 45.25 years. Within the female gender, the posterior mandible was still the most affected location, with 28 cases, followed by the posterior maxilla (12 cases), the anterior mandible (nine cases), and the anterior maxilla (four cases). The male gender, significantly less affected, showed slightly different frequencies considering locations: the posterior mandible was overall the most affected, with six cases, followed by the anterior mandible (three cases), the posterior maxilla (two cases), and the anterior maxilla (one case).

 

 

The bone‑related lesions of the jaws found in this study are described in Table 1. The most frequent were cemento‑osseous dysplasia, fibrous dysplasia, and ossifying fibroma, together representing 58 lesions of the total sample. Their clinical characteristics are described in Table 2 and Figure 2.

 

 

 

 

There was no association between the age group of the individuals investigated and the frequency of bone‑related lesions (p=0.06). The proportion of females was 82.4% in the group of individuals diagnosed with bone‑related lesions, against 64% in the group with other lesions; the measure of association showed that women were 62% more likely to have bone‑related lesions than other lesions (OR=0.38; CI [1.92‑0.75]). Bone‑related lesions were most frequent in the mandible (70.6% versus 29.4% in the maxilla) and the posterior region (73.5% versus 23.5% in the anterior region). The correlations between bone‑related lesions and the anatomical location regarding maxilla/mandible and anterior/posterior regions were statistically significant (p=0.013 and p=0.001, respectively). (Table 3).

 

 

Discussion

Bone‑related lesions in the maxillomandibular complex were present in 65 conclusive reports in this study, representing 3.17% of the total lesions biopsied in the CRLB – UEFS in this period, with an absolute frequency of 0.03. Jaafari and Akbari ⁽¹⁾ found a relative frequency of bone‑related lesions associated with jawbones of 15.9%, a value higher than that found in this study, which may be due to their collection period longer than 20 years.

The average age of patients was the variable with the greatest discrepancy within the literature. In this study, it was 45,23 years. Souto et al.,⁶ in a survey of 762 cases of maxillofacial lesions, had a patients’ mean age of 34 years. On the other hand, Jaafari and Akbari¹ had an average age of 28 years.

Thus, it is difficult to define a pattern among the average ages found by the studies.

In the present study, the most prevalent cases were female patients with lesions in the posterior region of the mandible.

A higher frequency of females and mandibular involvement in patients with bone‑related lesions of the jaws were also described by Souto et al..⁶ and Jaafari and Akbari.¹ This agreement can be justified not specifically due to it affecting more women, but possibly due to women being more aware of their health needs and possible alterations than men. This behavior causes women to seek healthcare more frequently, making these lesions more detectable and raising the number of cases in the female gender.

The most frequent lesions in this study were cemento‑osseous dysplasia, fibrous dysplasia, and ossifying fibroma.

The higher frequency of cemento‑osseous dysplasia can be explained by the significant demographic density of black women in the state of Bahia, Brazil, especially in the regions of Feira de Santana and Reconcavo Baiano, which have been influenced by slavery and afro‑descendants since the colonization of the country.⁷ Socio‑demographic aspects confirmed in the literature report the higher frequency of these cemento‑osseous dysplasias in black women. ^5,7

The most frequent bone‑related lesion associated with mandibular and maxillary bones differs among studies. In a study of intra‑osseous lesions detected in maxillary biopsies between 1998 and 2010, Jamshidi et al. ⁸ found 52 bone‑related lesions associated with maxillary bones, of which CGCG was the most frequent (42.3%). Peker et al..,⁹ in a 5‑year retrospective study of biopsies of mandible lesions, reported that the most frequent bone‑related lesion was the ossifying fibroma. On the other hand, Jaafari and Akbari,¹ in their clinicopathological study of intra‑osseous lesions in the southern Iranian population, found that CGCG was the most frequent, corresponding to 35.3% of the lesions associated with maxillary bones.

The clinical features of cemento‑osseous dysplasia found in this study were similar to the findings of Peker et al..,⁹ who reported a predominance of the female gender and posterior mandible regions in patients with this type of dysplasia. However, the age of patients with cemento‑osseous dysplasia varied considerably in most studies, as Muwazi and Kamulegeya, ¹⁰ when investigating the prevalence of maxillofacial fibro‑osseous lesions in Uganda, found a mean age of 49 years, Raubenheimer, Noffke and Boy ¹¹ reported 35 years, and Peker et al.. ⁹ 45 years.

The variables of the second most frequent lesion in this study, fibrous dysplasia, differed significantly from most articles available in the literature.^{1, 4, 8, 12 ‑ 14} However, Santos Neto et al.., ² when describing clinicopathological characteristics of 143 cases diagnosed with fibro‑osseous lesions, obtained results very close to those found in this study: mean age of 34 years and higher frequency in females and the posterior region of the mandible. On the other hand, Phattarataratip et al..,¹² when performing a clinicopathological analysis of 207 cases of benign fibro‑osseous lesions of the jaw, reported a mean age of patients with fibrous dysplasia slightly lower than that of this study (25 years) and the posterior maxilla as the most affected location, but also found a higher occurrence in females.

The ossifying fibroma, the third most frequent lesion in this study, presented clinical characteristics similar to those found by Jaafari and Akbari,¹ where females and the mandible were the most affected. These results differ from those by Mohanty et al..,¹⁵who, when performing a retrospective analysis of the ossifying fibroma of the mandibular‑maxillary bones, reported a patients’ mean age of 24 years and males as the most affected gender. The posterior mandible region was the most affected in most of the studies found.^{2, 4, 9, 10, 12, 14, 15}

According to the literature, few retrospective epidemiological studies have evaluated all lesions associated with the maxilla and mandible bones simultaneously. Generally, studies include only some of these lesions, such as bone dysplasia,^{11, 13} fibro‑osseous lesions,^{4, 10,12}or ossifying fibromas.¹⁵ In addition, most of the data on bone‑related lesions of the jaws come from retrospective studies, which are usually performed with data from histopathology laboratories; thus, some of these lesions are underreported.

Epidemiological surveys are a great indicator of the needs of a specific population (in this case, the Bahian population, mostly composed of brown or black individuals); thus, preventive and therapeutic actions derived from these should not be ignored by health professionals and government guidelines.

The inclusion of these oral lesions in the Health Department’s epidemiological bulletins, for example, can promote the implementation of preventive measures, as well as the training of professionals for an early and effective diagnosis and treatment, which can culminate in the reduction of costs and necessary health supplies.

Conclusions

Bone‑related lesions of the jaws biopsied in the CRLB – UEFS between 2006 and 2017 had a ratio of 1:31. The lesions studied affected mostly women and the posterior region of the mandible, and patients had a mean age of 45.2 years. The most common histopathological diagnosis was cemento‑osseous dysplasia, followed by fibrous dysplasia and ossifying fibroma.

 

References

¹. Jaafari‑Ashkavandi Z, Akbari B. Clinicopathologic Study of Intra‑ Osseous Lesions of the Jaws in Southern Iranian Population. J Dent (Shiraz). 2017;18:259‑64.

². Santos Netto JN, Cerri JM, Miranda AM, Pires FR. Benign fibro‑osseous lesions: clinicopathologic features from 143 cases diagnosed in an oral diagnosis setting. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:e56‑65.

³. Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018;472:331-9.

⁴. Kolomvos N, Theologie‑Lygidakis N, Christopoulos P, Iatrou I. Benign fibro‑osseous lesions of the jaws in children. A 12‑year retrospective study. J Craniomaxillofac Surg. 2013;41:574-80.

⁵. Barnes L, Eveson JW, Reichart P, Sidransky D editors. World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press, 2005. p.319‑27.

⁶. Souto ML, Piva MR, Martins‑Filho PR, Takeshita WM. Maxillofacial lesions: A census of 762 cases from the Federal University of Sergipe, Brazil. Rev Odontol UNESP. 2014;43:185‑90.

⁷. Demographic census. Brazilian Institute of Geography and Statistics (IBGE). 2010.

⁸. Jamshidi S, Shojaei S, Roshanaei G, Modabbernia S, Bakhtiary E. Jaw Intraosseous Lesions Biopsied Extracted From 1998 to 2010 in an Iranian Population. Iran Red Crescent Med J. 2015;17:e20374.

⁹. Peker E, Oğutlu F, Karaca İR, Gultekin ES, Cakır M. A 5‑year retrospective study of biopsied jaw lesions with the assessment of concordance between clinical and histopathological diagnoses. J Oral Maxillofac Pathol. 2016;20:78‑85.

¹⁰. Muwazi LM, Kamulegeya A. The 5‑year prevalence of maxillofacial fibro‑osseous lesions in Uganda. Oral Dis. 2015;21:e79‑85.

¹¹. Raubenheimer EJ, Noffke CE, Boy SC. Osseous dysplasia with gross jaw expansion: a review of 18 lesions. Head Neck Pathol. 2016;10:437-43.

¹². Phattarataratip E, Pholjaroen C, Tiranon P. A clinicopathologic analysis of 207 cases of benign fibro‑osseous lesions of the jaws. Int J Surg Pathol. 2014;22:326-33.

¹³. Cheng J, Wang Y, Yu H, Wang D, Ye J, Jiang H. An epidemiological and clinical analysis of craniomaxillofacial fibrous dysplasia in a Chinese population. Orphanet J Rare Dis. 2012;7:80.

¹⁴. Prabhu S, Sharanya S, Naik PM, Reddy A, Patil V, Pandey S. Fibro‑osseous lesions of the oral and maxillofacial region: retrospective analysis for 20 years. J Oral Maxillofac Pathol. 2013;17:36‑40.

¹⁵. Mohanty S, Gupta S, Kumar P, Sriram K, Gulati U. Retrospective analysis of ossifying fibroma of jaw bones over a period of 10 years with literature review. J Maxillofac Oral Surg. 2014;13:560-7.

 

^*Corresponding author:

Sheinaz Farias Hassam

E-mail address: sheinazhassam@hotmail.com

 

Ethical disclosures

Protection of human and animal subjects. The authors declare that the procedures followed were in accordance with the regulations of the relevant clinical research ethics committee and with those of the Code of Ethics of the World Medical Association (Declaration of Helsinki).

Confidentiality of data. The authors declare that they have followed their work center protocols on access to patient data and for its publication.

Right to privacy and informed consent. The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.

 

Conflict of interest

The authors have no conflicts of interest to declare.

 

Article history:

Received 23 May 2020

Accepted 28 October 2020

Available online 23 November 2020